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Photoacoustic thermal and optical characterization of blood


J. Balderas Lopez1, G. Espinoza-Chávez1 and L. Martinez-Pérez2

1Unidad Profesional Interdisciplinaria de Biotecnología del IPN, Basic Science Department, Mexico
2Unidad Profesional Interdisciplinaria de Ingeniería y Tecnologías Avanzadas del IPN, Bionic Department, Mexico

Keywords: photoacoustic techniques
property: thermal diffusivity, optical absorption
material: blood

A novel photoacoustic methodology, in the transmission configuration, for measurements of thermal and optical properties of fluids is introduced. The photoacoustic signal as a function of the sample’s thickness is involved, assuming the Beer-Lambert model for light absorption. The thermal diffusivity and optical absorption coefficient for blood samples at different concentrations were obtained, taking a wave-length of 405 nm [1], using the PA phase as experimental criteria for analysis. In particular a thermal diffusivity value for entire blood was measured as 0.00130 cm2/s and an optical absorption coefficient for a blood sample diluted 10 times was measured as 14.7 cm-1. Photoacoustic signal, on a difference of conventional spectroscopy, is very few affected by light dispersion for which is very adequate for optical analysis of samples with large absorption coefficients, as blood at the wave-length used in this work. This study could be useful for blood’s clinical trials as, for example, determine its amount of red cells and hemoglobin and, at this way, make diagnosis of some types of anemia.

References
  1. J. A. Balderas-Lopez, Rev. Sci. Instrum., 77, 086104 (2006).

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